15 Questions, Answered Honestly
Everything you need to know about depigmentation therapy with Monobenzone, from what it is, who it is for, how to use it, and what to expect, all in one place.
What is depigmentation therapy for vitiligo?
Depigmentation therapy is the process of permanently removing color from normal skin so it matches the white of vitiligo patches, creating a uniform skin tone across the body. It is usually chosen when repigmentation efforts have failed and there is little hope of restoring the original skin color.
How is depigmentation achieved?
By applying Monobenzone cream twice daily to areas where pigment remains until normal skin fades and matches the vitiligo spots. The process is gradual and also triggers new vitiligo spots that slowly merge toward total depigmentation.
Is Monobenzone a safe drug?
Yes. 20% Monobenzone (brand name Benoquin) has been FDA-approved since 1952 for depigmentation therapy, the first and last drug approved by the FDA for vitiligo.
It should not be used by pregnant women or breastfeeding mothers.
What is the difference between Monobenzone and Benoquin?
The brand name printed on the tube or packaging.
The active ingredient responsible for the depigmentation effect.
How do I know if I am the right candidate?
You are an ideal candidate if more than half of your body is affected with vitiligo. You can also consider this therapy if repigmentation has failed and vitiligo has spread to hard-to-treat areas.
Soles & feet
Lips
Genitalia
> 50% body coverage
My dermatologist refuses to prescribe Monobenzone. Can I still proceed?
Yes. Our group provides educational and emotional support when your dermatologist is not willing to help. We can also help connect you with suppliers who can send authentic Monobenzone with or without a prescription.
Where can I find authentic Monobenzone?
In several countries you can obtain Monobenzone with a valid prescription. In the US there are compounding pharmacies; in some European countries like Poland you can get a prescription and have the cream prepared quickly.
The internet is full of scammers selling fake Monobenzone at inflated prices. Ordering typically requires contacting suppliers via WhatsApp. They send a payment link and ship via DHL or EMS.
Recommended Suppliers
None of the group admins or moderators are commercially affiliated with these suppliers.
I found 60% and 80% Monobenzone online. Are they real?
No. These products are commonly sold by shady companies and often contain no Monobenzone or heavily diluted formulas mixed with other lightening agents.
✕ May reduce skin responsiveness
✕ Often zero active ingredient
Are there pills, capsules, or injections instead of cream?
No. Monobenzone is only available as a topical cream. Claims of pills, serums, soaps, or injections are a red flag.
Any product claiming to be Monobenzone in pill, serum, soap, or injectable form is not legitimate.
How should I use Monobenzone?
Apply a thin, even layer to areas where pigment remains (arms, legs, belly, etc.). Apply twice daily until desired results are achieved.
Apply twice daily, morning and evening, consistently for best results.
Thin, even layer only on areas with remaining pigment. Do not over-apply.
Are there precautions while using Monobenzone?
- Apply to areas covered by clothing when possible
- Wash hands thoroughly after every application
- Wash towels, clothes, and bed sheets separately
- Avoid intimacy while Monobenzone is on the skin
- Children and close family may be more vulnerable to transfer
I am pregnant or breastfeeding. Can I use Monobenzone?
No. Do not use Monobenzone if you are pregnant or breastfeeding.
Monobenzone can remain in your system for 4 to 5 months after stopping. Plan pregnancy at least 6 months after your last dose.
Can I use Monobenzone on my face?
Not advised. Facial skin is thin and sensitive, and there is a risk of eye exposure.
Prolonged use near the face may cause greying of eyebrows, eyelashes, or hairline.
What are the possible side effects?
Dryness, peeling, itching, and rashes are common early on and may last weeks to months.
Use moisturizers and aloe vera regularly. Anti-itch cream helps with irritation.
Antihistamines may help if itching is severe. Do not scratch.
What are the long-term side effects?
The main long-term consequence is permanent UV sensitivity. Strict sun protection is required for life.
☑ Hats & sunglasses
☑ UV-protective car window tinting
☑ UV-protective clothing
Still Have Questions?
This page covers the most common questions, but every journey is different. Join our community for personalised guidance, real experiences, and support from people who have been through the same process.
